P-106: Comparative Expression of The Stemness Gene Oct-4, Nanog, Sox-2 and Rex-1 in Normal Endometrium and in Endometriosis

Authors

  • Fsis Shariati Department of Genetics, Tehran Medical Sciences branch, Islamic Azad University, Tehran, Iran�(
  • P Afsharian Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive, ACECR, Tehran, Iran
  • P Ghoraeian Department of Genetics, Tehran Medical Sciences branch, Islamic Azad University, Tehran, Iran�(
  • R Aflatoonian Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive, ACECR, Tehran, Iran
  • S Mahdian Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive, ACECR, Tehran, Iran
Abstract:

Background Endometriosis is a gynecological disease defined as the presence of endometrial tissue outside the uterine cavity, which caused by various factors. Recent evidences support the presence of endometrial stem cells and their possible involvement in endometriosis. Related studies mainly focus on stemness-related genes, and pluripotency markers may play a role in the etiology of endometriosis.The aim of this study was to analyze transcription levels of the pluripotency factors sex-determine region Y-box 2 (SOX-2), Nanog homeobox (NANOG),Octamer binding protein 4 (OCT-4) and REX-1 (Zfp-42) in the endometrium of reproductive-age women with and without endometriosis. MaterialsAndMethods Ten ectopic and 10 eutopic tissue samples, as well as 23 normal endometrium speciments were tested in this study. The expression of OCT-4, NANOG, SOX- 2 and REX-1 genes were analyzed with quantitive real time polymerase chain reaction. Results The transcription levels of OCT-4, NANOG and SOX-2 mRNA were significantly increased in ectopic lesions compared with eutopic and control group, but the REX-1 mRNA increase was not significant between endometriosis and the control groups. Also there were difference in expression of these genes in normal endometrium during the menstrul cycle.)B Conclusion Based on our data we can conclude that differential transcription of pluripotency factors are involved in ectopic endometrium and the expression of OCT-4, NANOG and SOX-2 may contribute to the pathophysiology of endometriosis by stimulating the migration and invasion activity of endometrial cells.

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volume 9  issue 2

pages  87- 87

publication date 2015-09-01

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